PROTEOMIC ANALYSIS OF S-ACYLATED PROTEINS IN HUMAN RETINAL PIGMENT EPITHELIAL CELLS AND THE ROLE OF PALMITOYLATION OF NIEMANN-PICK TYPE C1 PROTEIN IN CHOLESTEROL TRANSPORT

Proteomic analysis of s-acylated proteins in human retinal pigment epithelial cells and the role of palmitoylation of Niemann-Pick type C1 protein in cholesterol transport

Palmitoylation is a dynamic process that regulates the activity of the modified proteins.Retinal pigment epithelial (RPE) cells play pivotal roles in the visual cycle and maintaining healthy photoreceptor cells.Dysfunctional RPE cells are often associated with degenerative retinal diseases.The aim of the study was to identify potentially palmitoyla

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Clinical feasibility study of transcatheter edge-to-edge mitral valve repair in dogs with the canine V-Clamp device

ObjectiveTo determine procedural feasibility, safety, and short-term efficacy in dogs with severe degenerative mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER) with a canine-specific device.DesignProspective, single-arm (uncontrolled), single-institution clinical feasibility study.AnimalsFifty client-owned dogs with sev

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